Syndromes for Monday, June 1st, 2026

Contributed by Pamela Youde Nethersole Eastern Hospital, Hong Kong
Leung San Yu.

History

A term neonate with unremarkable antenatal and perinatal history, presented with left lower limb swelling with overlying hyperpigmentation upon birth. Physical examination showed increased temperature, with preserved perfusion and pulse over left lower limb. Cardiovascular and neurological examinations were normal. Patient remained active, stable and afebrile. Blood tests were unremarkable with normal platelet count and clotting profile. Magnetic resonance imaging (MRI) of bilateral lower limbs was later performed.

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Question

What is the most likely diagnosis? (choose one)

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